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KMID : 1149220050130010001
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Korean Journal of Oriental Medical Prescription
2005 Volume.13 No. 1 p.1 ~ p.7
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A Study of Okchun-San Formulation for Freeze Drying Capsulation
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Oh Myung-Sook
Kim Do-Rim
Kang Ji-Wung
Chang Mun-Seog
Park Sun-Min
Ko Byoung-Seob
Park Seong-Kyu
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Abstract
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Objective : Okchun-San(OCS) is known as an effective herbal medicine on Type 2 diabetes. We performed to change OCS formulation for freeze drying capsulation.
Methods :The mixtures of OCS were extracted with water. finally, the filtered solution were evaporated and lyophilized to dry granules. The various ratio of excipients were studied to determine the formation for capsulizing. The samples were inspected for any difference in color, taste and appearance.
Results: The prepared form of OCS were dried and weighted 260kg. The lyophilized dry powder yielding 40kg. The suitable ratio of OCS-dry powder and excipient was 10:1. The average weights of On and placebo capsules were 440±5.28mg, 465±7.95mg, respectively. There was no notable change in color and appearance for both capsuled samples throughout the study period.
Conclusions: Therefore in can be concluded that freeze drying capsulation is appropriate form of OCS.
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KEYWORD
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Okchun-San(OCS), freeze drying, capsulation, formation
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